Be prepared for disruptions and possible isolation with the Winter Storm Warning.
Environment Canada stresses you should have an emergency kit at home and in your vehicle and if you do have to travel you should expect delays.
Meteorologist Steven Flisfeder says make sure you keep your snow tires on and keep some food prepared just in case the power goes out.
He calls it an intense storm and people should be prepared for what is coming.
Many shelves at grocery stores across the region were bare Tuesday as people came in droves to stock up.
Snowfall amounts will now vary depending on where you live according to Environment Canada.
The Dryden and Kenora area may see 35 centimetres by Friday, while Sioux Lookout and Pickle Lake may be hit with 60 centimetres.
If you are headed east, Thunder Bay is actually under a Rainfall Warning.
(With files from Tim Davidson)